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    NSCLC 360 - Leveraging Multi-Omics Data for a Holistic and Explainable Decision Support for Non Small Cell Lung Cancer Management
    (Institute of Electrical and Electronics Engineers Inc., 2025-07-03) Pirabaharan, A; Irfan, A. A.; Lareef, W; Ahamed, S; Rathnayake, S; Shyamalee, T
    Non-Small Cell Lung Cancer (NSCLC) remains a leading cause of cancer-related mortality, with existing diagnostic and prognostic models often failing to capture the complexity of tumor biology. This study proposes a holistic and explainable decision support system that integrates multi-omics data - including genomics, transcriptomics, and proteomics - along with advanced machine learning (ML) and deep learning (DL) techniques to enhance NSCLC detection, prognosis prediction, complication forecasting, and recurrence assessment. To address the challenge of interpretability in AI-driven healthcare, we incorporate Explainable AI (XAI) methods such as SHAP and LIME, ensuring model transparency and clinical trust. Additionally, traditional statistical models like Cox proportional hazards regression are combined with ML approaches for robust survival analysis, while modern AI architectures, including Vision Transformers and multi-task learning models, improve tumor localization and TNM classification. By developing an interpretable and clinically meaningful AI-based decision support system, this research aims to advance personalized lung cancer management and improve patient outcomes through seamless integration into clinical workflows.
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    PregAssist: Pregnancy Support Mobile Application for Pregnant Mothers and Doctors
    (Institute of Electrical and Electronics Engineers Inc., 2026-05-22) Buddika, B. P; Jayasinghe N.; Perera A.N.M; Wijethunga D.N; Weerasinghe, M; Dunuwila, O
    Pregnant care involves constant follow-ups, timely risk detection, and successful interactions between mothers and medics. This paper introduces PregAssist, a mobile integrated support system that is a synthesis of four products, including fetal health decision support, physical health risk prediction, AI-based mental health monitoring, and AR-driven emergency training. The fetal health module provides explainable and offline-capable cardiotocography (CTG) classification to assist clinical decision-making. XGBoost classifier with SHAP-based interpretability is used to analyze physical risks to generate individual recommendations and alerts. Mental health assessment integrates questionnaire-based indicators with CNN-driven facial emotion recognition, while federated learning preserves data privacy through on-device training. AR-based deterministic expert system offers protocol-adherent emergency simulations to improve preparedness activity when facing high-level of risk. Through the convergence of predictive analytics, explainable AI, privacy preserving learning, and training design, PregAssist assists in proactive maternal attention in urban and resource constrained environments via combining a hybrid mobile architecture.