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Prof. Charitha Jayaruk Thambiliyagodage

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https://orcid.org/0000-0003-0906-4441

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https://scholar.google.com/citations?user=kdc5vsQAAAAJ

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Prof. Charitha Jayaruk Thambiliyagodage

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Jayaruk is a graduate of the University of Colombo. He pursued his PhD in Chemistry from The University of Alabama, USA. He has specialized in Materials, Analytical and Physical Chemistry. Currently, he is working as an Assistant Professor at the Department of Applied Sciences, SLIIT. He is the coordinator of the BSc Biotechnology degree programme. He has been awarded the chartered chemist designation by the Institute of Chemistry, Ceylon. He supervises Postgraduate students at the University of Colombo and the University of Kelaniya and supervises undergraduate students at the Institute of Chemistry. He is interested in doing research on using nanomaterials in water purification and as antimicrobial reagents. Further, he is interested in researching on algae and plant materials for their pharmaceutical and cosmeceutical activities. He has specialized in many instruments like Transmission Electron Microscope (TEM), Scanning Electron Microscope (SEM), X-Ray Diffractometer (XRD), X-Ray Photoelectron Spectrometer (XPS), Gas chromatograph-Mass spectrometer (GC-MS), Raman Spectrometer, FT-IR spectrometer, UV-Visible Spectrophotometer, Brunauer-Emmett-Teller (BET) surface area analyzer etc. He is interested in practical-based science education and believes in uplifting the research culture among upcoming scientists in the country.

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Application of nanomaterials for water purification Novel nanomaterials incorporated cosmeceuticals and pharmaceuticals Natural material based neutraceuticals Alternative energy sources Novel packaging materials Environmental Chemistry

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search.filters.applied.f.isAuthorOfPublication: search.filters.isAuthorOfPublication.95d00db3-68ae-4943-bcef-3692a59bbcd5Author: search.filters.author.Jayanetti, MSubject: search.filters.subject.Chitosan

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Now showing 1 - 2 of 2
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    PublicationEmbargo
    Kinetic study of in vitro release of curcumin from chitosan biopolymer and the evaluation of biological efficacy
    (Elsevier B.V., 2024-09) Wijayawardana, S; Thambiliyagodage, C; Jayanetti, M
    Sustained release of curcumin from the polymeric carrier system chitosan, a natural biopolymer material derived from chitin originated from natural shrimp shell waste, was studied. Six kinetic models, zero order, first order, Korsmeyer–Peppas (KP), Peppas – Sahlin (PS), Higuchi, and Hixson–Crowell, were applied to study the drug release kinetics. The release mechanism of the drug from the curcumin-chitosan composite was evaluated by changing the pH, ionic strength of the release media, and drug concentration. KP and PS models were selected among the studied models to investigate the drug release mechanism from the chitosan biopolymer based on the R2 values (R2 > 0.99). The model constants m in the PS model and n in the KP model stand for the case II relaxation and Fickian diffusion contribution, respectively. The n being < 0.43 in the KP model suggests that the Fickian diffusion governs the drug release. Furthermore, there is a noticeable difference between the values obtained for model parameters m and n in the PS and KP models, indicating that Case II relaxation and Fickian diffusion play crucial roles in the curcumin release mechanism from chitosan. Polymer relaxation has been proven to play a predominant role in releasing curcumin from the composite at lower ionic strengths and higher pH values. Anti-inflammatory activity was tested using the egg-albumin denaturation assay, and the diphenyl-2-picrylhydrazyl assay was carried out to determine the antioxidant activity of the composite. The composite material showed IC50 values of 0.29 mg/ mL and 1.08 mg/ mL for anti-inflammatory and anti-oxidant activities, respectively. The drug composite has shown antibacterial activity against Pseudomonas aeruginosa, Klebsiella pneumoniae, and Staphylococcus aureus, which are highly effective against S.aureus. The resulting inhibition zones for S.aureus were 13.34 ± 0.34 mm, 16.34 ± 0.60 mm, and 13.34 ± 0.73 mm for 5, 10, and 20 mg/ml concentrations, respectively. The drug composite’s minimum inhibitory concentration/ minimum bactericidal concentration ratio for S.aureus, K. pneumoniae, and P.aeruginosa was greater than 4, suggesting that they cause bacteriostatic effects.
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    PublicationOpen Access
    A Study on Conscinium fenestratum and Chitosan Biopolymer Composite for Ayurvedic Drug Delivery
    (Faculty of Humanities and Sciences, SLIIT, 2024-12-04) Alwis, M; Jayanetti, M; Thambiliyagodage, C
    This study delves into the synergisti c amalgamati on of Coscinium fenestratum, an Ayurvedic medicinal plant, and chitosan biopolymer. This results in the innovati ve Venivel Chitosan Composite, which has established a pioneering drug delivery system. Subsequently, the composite material, Venivel Chitosan Composite, was formulated by integrati ng Coscinium fenestratum extract and chitosan biopolymer. Structural characteristi cs of Chitosan biopolymer and Venivel Chitosan Composite were determined via scanning electron microscopy (SEM), off ering valuable insights into their morphological features. Furthermore, a comprehensive characterizati on of the composite was achieved through the analysis of X-ray diff racti on (XRD) patt erns, elucidati ng its crystalline structure. A meti culous examinati on of the in vitro drug release profi le revealed a predominant diff usion mechanism, indicati ng the potenti al suitability of this system for applicati ons in wound healing treatments. In conclusion, integrati ng Coscinium fenestratum with chitosan biopolymer presents a versati le composite with promising anti bacterial, anti oxidant, and anti - infl ammatory properti es, elevati ng its potenti al for targeted and controlled ayurvedic drug delivery applicati ons.