SLIIT Conference and Symposium Proceedings
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All SLIIT faculties annually conduct international conferences and symposiums. Publications from these events are included in this collection.
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Publication Open Access Predictive Modeling for Personalized Cancer Therapy Using Reinforcement Learning(Faculty of Engineering, 2025-09-09) Edirisinghe M.M; Gunarathne,J H M S MAdaptive therapy is transforming cancer treatment by enabling dynamic, patient-specific interventions that adapt to tumor progression and individual variability. Unlike traditional fixed-dose regimens, adaptive therapy leverages the evolutionary dynamics of tumors to extend treatment effectiveness and delay resistance. Reinforcement Learning (RL), an area of artificial intelligence focused on sequential decision-making, offers a robust framework for optimizing these adaptive strategies. RL can learn optimal treatment policies by interacting with computational models of tumor growth and drug response, continuously adjusting regimens based on observed tumor states, resistant cell populations, and biomarkers. This approach allows for the creation of personalized therapies that maintain long-term tumor control while minimizing toxicity and the emergence of resistance. The integration of RL into predictive modeling for cancer therapy represents a paradigm shift, enabling smarter, safer, and more effective treatments that are dynamically tailored to each patient’s evolving disease. This paper reviews the foundational concepts of adaptive therapy and RL discusses tumor modeling approaches, examines RL algorithms, and addresses current challenges and future directions in the field.Publication Embargo A Comparative Study between Tissue Biopsy and Liquid Biopsy in the Diagnosis of Cancer(Faculty of Humanities and Sciences - SLIIT, 2021-03-26) Balaakshayan, B.; Sathsarani, A. M. A.; Kumarasinghe, N. M.; Rathnayake, R. M.; Perera, M. R. N.; Annan, N.J.Tissue biopsy is invasive, and it can be accompanied by surgical complications and pain. Concept of liquid biopsy is the analysis of tumors utilizing biomarkers circulating in liquids, for example, the blood. Samples may be insufficient and need repeating- Tissue biopsies may not generally be effortlessly acquired and frequently may include the utilization of progressively obtrusive methodology. In tissue biopsy, a long thin needle is inserted into the area of suspicion. Liquid biopsy is a test done on a blood sample to find DNA fragments from cancer cells or cancer cells in a blood clot. The basic needle biopsy uses a large needle with a cutting tip to draw a strip of tissue from a suspicious area. Liquid biopsies can be used to help detect cancer at an early stage. Most pathologists depend on playing out a tissue biopsy to analyze a malady and they are prepared explicitly to perform different cytological tests on the submitted tissue example. The needle used throughout a core biopsy is Associate in Nursing empty cylinder that allows to untangle a core of tissue for testing. Tissue diagnostic test to assist Associate in Nursing analyze Associate in Nursing upset or to preclude an upset or condition. Advantages and Disadvantages of Liquid biopsy Advantages of Liquid biopsy ct-DNA and CTCs represent the overall tumor heterogeneity and help in the complete assessment of patient's resistance and in predicting response to 1790M- targeted inhibitors.