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Author: search.filters.author.Liyanage, R

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Now showing 1 - 4 of 4
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    PublicationOpen Access
    Anthocyanin (ATH)-incorporating polyvinylpyrrolidone-ethyl cellulose-(2-hydroxypropyl)-β-cyclodextrin (PVP–EC–BCD) nanofiber-based pH sensor for ocular pH detection during accidental chemical spills
    (Royal Society of Chemistry, 2026-02-03) Sandaruwan, B; Liyanage, R; Costha, P; Dassanayake, R.S; Wijesinghe, R.E; Herath H.M.L.P.B; Nalin de S.K.M; de Silva, R.M; Rajapaksha, S.M; Wijenayake, U
    The existing ocular pH detection methods encounter numerous limitations, including low accuracy, poor sensitivity across a wide pH range, and patient discomfort, highlighting the need for innovative approaches. A novel biosensor for ocular pH detection has been developed to assess ocular health and chemical injuries in clinical settings. This study uses the pH-sensitive properties of anthocyanins (ATHs), natural pigments extracted from butterfly pea flowers, to develop a novel pH-responsive nanofiber mat. ATHs are integrated into a polymer blend containing polyvinylpyrrolidone (PVP), ethyl cellulose (EC), and (2-hydroxypropyl)-β-cyclodextrin (BCD) to fabricate electrospun nanofibers. The acquired characterization, employing scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and thermogravimetric analysis (TGA), confirmed the successful fabrication of the ATH-infused nanofibers with a mean diameter ranging from 121 to 396 nm. Four formulations were tested: PVP:EC:BCD:ATH (18 ppm), PVP:EC:BCD:ATH (25 ppm), PVP:EC:BCD:ATH (35 ppm), and PVP:EC:BCD:ATH (50 ppm). Among them, the 50 ppm ATH-incorporating nanofiber mat exhibited the best performance in terms of color clarity, response time, and pH sensitivity. The fabricated 50 ppm ATH incorporating nanofiber mat demonstrated a rapid pH response time of less than 5 seconds (s) while exhibiting a color variation from pink to blue to green across the pH range of 1 to 12, providing a rapid and accurate method for visual pH detection. Based on the color performance of the 50 ppm ATH-incorporating system, a standardized color reference chart was developed to serve as a practical and visual guide for estimating pH levels in clinical applications. Zebrafish toxicity assays were conducted further to validate the safety and biocompatibility of the developed sensor, revealing no significant toxic effects across the range of ATH concentrations.
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    PublicationOpen Access
    FADING BEFORE THEY BLOOM’: CHILD MORTALITY IN SRI LANKA IN HOUSEHOLDERS
    (Sri Lanka Forum of University Economists,Uva Wellassa University of Sri Lanka, 2021-01-21) Liyanage, R; Adikari, H; Wanigarathna, N; Udalagama, R; Jayathilaka, R
    The future human capital of any country is “children”. Hence, every child in this world has a right to have a good quality life. Children are a valuable investment in a country. In 1990, 12.6 million child deaths have taken place but in 2016, it drops to 5.6 million. Basically, universal child mortality rate has declined by over half between 1990 and 2016 (Rodriguez 2016). This progress in child survival indicates the development of global health. However, at present, globally approximately 15,000 under five-year old deaths occur per day and 5.3 million annually. Majority occur in Sub-Saharan Africa and South Asia. Moreover, the Department of Census and Statistics (2016) highlighted that infant mortality or early childhood mortality is a measure of socioeconomic development of a country; also, it’s a good measure of the quality of life. Many rigorous studies on child mortality regarding household income and expenditure, household wealth and also socioeconomic determinants of child mortality have been conducted especially in the developing countries in Asian and African regions (Nyamuranga and Shin 2019), but limited scale in Sri Lanka
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    PublicationOpen Access
    Cherish your children: socio-economic and demographic characteristics associated with child mortality
    (BioMed Central, 2021-12) Jayathilaka, R; Adikari, H; Liyanage, R; Udalagama, R; Wanigarathna, N
    Background: The United Nations Interagency Group for Child Mortality Estimation (UNIGME) indicates that child mortality is the death rate of children between age zero to five. The importance of this area of research is high where worldwide a number of studies have been led on infant and child mortality, despite limited research discoveries with regards to Sri Lanka. The aim of this study is to investigate the socio-economic and demographic characteristics associated with child mortality in Sri Lanka. Methods: Using the context of Sri Lanka as a case study, this study carried out based on data gathered from the micro level national survey. Using the logit regression model through the step-wise technique, the study investigate the socio-economic and demographic characteristics associated with child mortality in Sri Lanka. Results: According to the generated results, place of residence province-wise, household head’s education level and source of drinking water have negative effect (lower risk) on child mortality in Sri Lanka. Exceptionally, the Western province has the highest negative effect on child mortality which demonstrates it as the least harmful region in Sri Lanka in child endurance. Household heads who owns private entities and Sri Lankan Moors has a positive effect on child mortality as well. Conclusion: This study is helpful to address the population health of local arena and results can be supportive to the government and policymakers to gain an overview of physical health status of the country and able to uplift their policies based on the new findings
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    PublicationOpen Access
    Cherish your children: socio-economic and demographic characteristics associated with child mortality
    (Springer Nature, 2021-06-24) Jayathilaka, R; Adikari, H; Liyanage, R; Udalagama, R; Wanigarathna, N
    Background: The United Nations Interagency Group for Child Mortality Estimation (UNIGME) indicates that child mortality is the death rate of children between age zero to five. The importance of this area of research is high where worldwide a number of studies have been led on infant and child mortality, despite limited research discoveries with regards to Sri Lanka. The aim of this study is to investigate the socio-economic and demographic characteristics associated with child mortality in Sri Lanka. Methods: Using the context of Sri Lanka as a case study, this study carried out based on data gathered from the micro level national survey. Using the logit regression model through the step-wise technique, the study investigate the socio-economic and demographic characteristics associated with child mortality in Sri Lanka. Results: According to the generated results, place of residence province-wise, household head’s education level and source of drinking water have negative effect (lower risk) on child mortality in Sri Lanka. Exceptionally, the Western province has the highest negative effect on child mortality which demonstrates it as the least harmful region in Sri Lanka in child endurance. Household heads who owns private entities and Sri Lankan Moors has a positive effect on child mortality as well. Conclusion: This study is helpful to address the population health of local arena and results can be supportive to the government and policymakers to gain an overview of physical health status of the country and able to uplift their policies based on the new findings.